Yes. USB Cables will work with multiFLEX. The settings are generally related to the radio, depending on the source selection. Some sources may not be as useful in a multiple client scenario since more than one client could impact the USB Cable band/frequency (e.g. Active Slice). When a source is used, like a particular RX Antenna, the last Slice using that antenna to change frequency will trigger the USB Cable to update (last one wins).