Yes. The PowerGenius XL is an ideal amplifier to use with SmartSDR with multiFLEX. The integration showing the power output directly in the display and the ability to instantly switch to barefoot all from the SmartSDR screen makes it a breeze to operate. Other amplifiers will also work with multiFLEX provided that they can switch in an appropriate time (~10ms) or an appropriate delay is added to compensate for any switching delays (as would be customary for typical operation).